IC50 - Wikipedia
WebEC 50 represents the dose or plasma concentration required for obtaining 50% of a maximum effect in vivo. [1] IC 50 can be determined with functional assays or with competition binding assays. Sometimes, IC 50 values are converted to the pIC50 scale.
半数抑制浓度 - 维基百科，自由的百科全书
Web半数抑制浓度 （ IC50 ）是物质抑制特定生物或生化功能的 效力 的量度。. IC 50 是一种定量测量，表明需要多少特定的 抑制 物质（例如药物）才能 体外 抑制50%给定生物过程或生物成分。. [1] 生物成分可以是 酶 、 细胞 、 细胞受体 或 微生物 。. IC 50 值通常表示 ...
IC50和EC50是啥？傻傻分不清 - 知乎 - 知乎专栏
Web下面我们简单介绍下这2个概念，帮大家区分清楚。. 一、定义. 1. IC50. IC50 (half maximal inhibitory concentration)是指被测量的拮抗剂的半抑制浓度。. 它能指示某一药物或者物质 (抑制剂)在抑制某些生物程序 (或者是包含在此程序中的某些物质，比如酶，细胞受体或是微 ...
半抑制浓度 - 百度百科
Web半抑制浓度（或称半抑制率），即IC50。. 在间接竞争ELISA 标准曲线 中是一个非常重要的数据，标准曲线是一个S型曲线。. ICELISA中，不添加抑制物质的对照孔的OD值为B0，添加了抑制物质的孔的OD值为B，B/B0称为结合率，在结合率为50%时所对应的抑制物质的浓度 …
ic50 - 搜狗百科
WebMay 17, 2023 · IC50 (half maximal inhibitory concentration)是指被测量的拮抗剂的半抑制浓度。. 它能指示某一药物或者物质 (抑制剂)在抑制某些生物程序 (或者是包含在此程序中的某些物质，比如酶，细胞受体或是微生物)的半量。. 在凋亡方面，可以理解为一定浓度的某种药 …
The IC(50) concept revisited - PubMed
WebThe ability to accurately measure the concentration of the inhibitor which is required to inhibit a given biological or biochemical function by half is extremely important in ranking compounds. Since the concept of the half maximal inhibitory concentration (IC (50)) is used extensively for studying reversible inhibition enzymatic reactions, it ...
The changing 50% inhibitory concentration (IC50) of cisplatin: a …
WebOct 10, 2016 · The changing 50% inhibitory concentration (IC50) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer - PMC. Journal List. Oncotarget.
Determination of half-maximal inhibitory concentration using ... - PubMed
WebSep 1, 2016 · Half-maximal inhibitory concentration (IC50) is the most widely used and informative measure of a drug's efficacy. It indicates how much drug is needed to inhibit a biological process by half, thus providing a measure of potency of an antagonist drug in pharmacological research.
Determination of half-maximal inhibitory concentration using …
WebSep 1, 2016 · The half-maximal inhibitory concentration (IC 50) is the most widely used and informative measure of a drug’s efficacy.It indicates how much drug is needed to inhibit a biological process by half, thus providing a measure of potency of an antagonist drug in pharmacological research.
When Does the IC50 Accurately Assess the Blocking Potency of a …
WebMar 3, 2020 · Here, we attempt to shed light on the relevance of the IC 50 as an indicator of the IKr blocking potency of a compound and to improve the characterization of its blocking effects using a highly detailed Markov model considering a wide range of …
Skip to content